What did your wife wash Charley's face with? It's probably some kind of puppy acne. Find a mild acne wash and scrub her little chinny. Do this twice a day, especially after eating (food gets into the wrinkles and bacteria grows) for a week and it should clear up. To prevent it from coming back make sure to take a damp paper towel and wipe her mouth and jowels well after eating.
Mo - Mom to Delilah, CGC (flashy fawn, floppy and docked), and the kitties, Cosmic Charlie (RIP Charlie 3-17-09) and Crystal, rescue kitty, with me since 2/08